The nasopharynx is located behind the nose and above the back of the throat. On each side of the nasopharynx are the Eustachian tubes which connect to the ears. Nasopharyngeal cancer typically arises in the thin lining of the nasopharynx in the space behind the Eustachian tubes. It is more common in Southern China and most often found in men.

Symptoms
Since the tumour grows within air-filled spaces, it may not exhibit symptoms until it is large enough to block passage of air or smell or vision. They include:

• A lump in the neck caused by a swollen lymph node

• A sensation of fullness or pressure in the ear

• Popping noises, hearing loss, and ear infection

• Nasal regurgitation of food and liquids

• Impaired (hypernasal) speech

Tumours of the Pituitary Gland and Skull Base

• Headaches

In advanced cases, infiltration of NPC into the spine can cause

• Stiff neck

• Pain

• Neck instability

The preferred surgical treatment for NPC is the Endoscopic Endonasal Approach ODONTOID PANNUS (Rheumatoid Pannus, Odontoid Synovial Cyst) Odontoid pannus is abnormal tissue that grows in the region of the odontoid process – a toothlike projection at the back of the second cervical vertebra which serves as the pivot for the turning of the head.

This membrane of granulated tissue forms most often as a result of rheumatoid arthritis, in which the condition is called a rheumatoid pannus. Odontoid pannus may also develop due to severe trauma to the neck at the second cervical vertebra.

A similar (although rarely diagnosed) condition which has similar symptoms and treatment is the odontoid synovial cyst.

Rheumatoid pannus
Rheumatoid arthritis (RA) is a progressive auto-immune disease that causes chronic inflammation of the joints. When it attacks, it usually begins in the synovium – a kind of tissue that lines the joint capsule. Cells in the synovium begin to grow and divide abnormally (synovitis) causing a thickening of the synovium resulting in an inflamed and swollen joint.

As it progresses, the synovium can grow larger and form an inflamed, granulated sheet of tissue called rheumatoid pannus. This tissue will spread from the synovial membrane, causing considerable destruction as it invades the subchondral bone.

Symptoms of cervical–spinal abnormalities develop in approximately 60% to 80% of patients with rheumatoid arthritis. When RA invades the cervical spine, the resulting extension of pannus into the spinal canal may compress the brain stem, spinal cord and vertebral arteries causing severe pain and disability.

Left untreated rheumatoid pannus can even result in sudden death.

Treatment
An instability of the joints results in progressive deformity. Generally, in order to stabilise the joints, cranio-cervical fusion is recommended.

If the patient suffers from compression of the spinal cord or brainstem, surgery to decompress them is recommended. In these cases, the Endoscopic Endonasal Approach is best.