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Enlarged Uterus: Causes, Symptoms & Treatments

A women’s uterus is the size of a clenched fist but can grow as big as a soccer ball or larger during pregnancy. In addition to pregnancy, there are many other reasons why a woman’s uterus may become enlarged.

An enlarged uterus can be the result of a medical condition that not only causes it to grow but also to bleed and become painful. A condition that results in an enlarged uterus may require treatment.

Causes and risk factors:

a uterus

An enlarged uterus can cause pain and other health complications.

A woman can be unaware that she has an enlarged uterus. Most often, women discover they have a problem during a pelvic exam.

It is possible a woman may notice a bloated belly or that clothes seem too tight, but for most, a diagnosis of an enlarged uterus is unexpected.

There are multiple reasons why the uterus may become enlarged. An enlarged uterus may be more common in menopausal women, but women in their childbearing years can develop this condition too.

Fibroids

Fibroids are one of the most common causes of an enlarged uterus. Fortunately, fibroids are noncancerous.

Fibroids are small lumps that can weigh up to several pounds. They are found along the walls of the uterus.

Fibroids may be asymptomatic, or may cause pain and heavy menstrual cycles.

Fibroids also put pressure on the bladder and the rectum, causing frequent urination and rectal pressure. If they get too big, fibroids may cause the uterus to become enlarged.

Adenomyosis

Adenomyosis is a noncancerous condition that mimics symptoms of fibroids. It results in the lining of the uterus becoming embedded directly in the muscle wall of the uterus. During the menstrual cycle, the cells of the muscle bleed, causing pain and swelling.

The adenomyoma is the swollen part of the uterine wall. Upon examination, the adenomyoma feels like a fibroid, and it may even be confused with one on an ultrasound.

Adenomyosis may not cause any symptoms. In other severe cases, it can lead to heavy bleeding and cramping during menstruation.

One study of 985 women reported in the medical journal Human Reproduction found that adenomyosis was present in approximately 20 percent of participants.

However, all participants in the study had attended a gynecology clinic with existing symptoms. It is possible, then, that the prevalence of adenomyosis is higher in the general population.

Polycystic ovarian syndrome

Polycystic ovarian syndrome (PCOS) also causes an enlarged uterus. It is the result of hormonal imbalances in menstruation and the shedding of the endometrial lining of the uterus. It affects 1 in 10 women of childbearing age.

The body typically sheds the endometrial lining during the menstrual cycle, but in some women, the lining is not entirely discarded and interferes with their monthly cycle.

The accumulation of the endometrial lining causes inflammation and enlargement of the uterus.

Endometrial cancer

According to the National Cancer Institute (NCI), endometrial cancer is most often diagnosed in women ages 55 to 64. The NCI estimates there will be 61,380 new cases in 2017.

One of the symptoms of endometrial cancer is an enlarged uterus, although it can also be an indicator of advanced stage cancer.

Menopause

Perimenopause, which is the stage before a woman enters menopause, is another cause of uterine enlargement and is due to fluctuating hormone levels.

Inconsistent hormone levels during this period of a woman’s life may cause the uterus to enlarge. Most the time, the uterus goes back to its normal size once a woman has reached menopause.

Ovarian cysts

Ovarian cysts are fluid-filled sacs that grow on the surface of an ovary or within it. In most cases, ovarian cysts are harmless.

But if cysts become too large, they can cause an enlarged uterus, as well as more serious complications.

Symptoms

In addition to its physical size, an enlarged uterus may cause the following symptoms:

An enlarged uterus may cause a number of symptoms, such as weakness, cramping, constipation, pain during sex, and menstrual abnormalities.
  • menstrual cycle abnormalities, such as heavy bleeding and cramping
  • a mass over the lower abdomen
  • anemia due to excessive menstrual bleeding
  • general weakness and paleness
  • weight gain at the waistline, from the uterine overgrowth
  • pressure symptoms on the uterus and surrounding structures
  • cramping in the pelvic area
  • constipation
  • swelling and cramping in the legs
  • backaches
  • urinary frequency and urgency
  • watery discharge
  • bleeding after menopause
  • pain during sexual intercourse

Symptoms of an enlarged uterus can vary depending on what has caused them.

Diagnosis

Many women do not know they have an enlarged uterus. Usually, a doctor discovers this condition during a physical exam or with imaging tests.

In most cases, an enlarged uterus is a benign condition and does not require treatment unless a person has severe symptoms and pain.

Complications

The causes of uterine enlargement may lead to complications if the symptoms of the underlying condition worsen or are left untreated.

Complications may include:

  • hysterectomy (removal of all or part of the uterus)
  • loss of fertility
  • miscarriage and other pregnancy complications
  • infection due to uterine inflammation

Treatment

Most causes of an enlarged uterus do not require treatment, although some women may need medication for pain relief. Birth control pills and intrauterine devices (IUDs) containing progesteronecan ease the symptoms of heavy menstrual bleeding.

In very severe cases, some women may need a hysterectomy.

With uterine cancer, surgical removal of the uterus, fallopian tubes, and ovaries may be the recommended course of treatment. Following surgery, women may undergo chemotherapy and radiation.

Conclusion

An enlarged uterus is usually not an indication of a serious health condition. Doctors will use CT scans and ultrasounds to determine the exact cause of enlargement.

Most of the time, no treatment is necessary and doctors will just monitor the cause of enlargement. They may also carry out some tests to rule out uterine cancers.

It is important for women to have routine pelvic exams with a gynecologist to detect any problems early and prevent complications.

Prolapsed Uterus: Causes, Symptoms & Treatments

What is a prolapsed uterus?

The uterus (womb) is a muscular structure that’s held in place by pelvic muscles and ligaments. If these muscles or ligaments stretch or become weak, they’re no longer able to support the uterus, causing prolapse.

Uterine prolapse occurs when the uterus sags or slips from its normal position and into the vagina (birth canal).

Uterine prolapse may be incomplete or complete. An incomplete prolapse occurs when the uterus is only partly sagging into the vagina. A complete prolapse occurs when the uterus falls so far down that some tissue protrudes outside of the vagina.

What are the symptoms of uterine prolapse?

Women who have a minor uterine prolapse may not have any symptoms. Moderate to severe prolapse may cause symptoms, such as:

  • the feeling that you’re sitting on a ball
  • vaginal bleeding
  • increased discharge
  • problems with sexual intercourse
  • the uterus or cervix protruding out of the vagina
  • a pulling or heavy feeling in the pelvis
  • constipation or difficulty passing stool
  • recurring bladder infections or difficulty emptying your bladder

If you develop these symptoms, you should see your doctor and get treatment right away. Without proper attention, the condition can impair your bowel, bladder, and sexual function.

Are there risk factors?

The risk of having a prolapsed uterus increases as a woman ages and her estrogen levels decrease. Estrogen is the hormone that helps keep the pelvic muscles strong. Damage to pelvic muscles and tissues during pregnancy and childbirth may also lead to prolapse. Women who’ve had more than one vaginal birth or are postmenopausal are at the highest risk.

Any activity that puts pressure on the pelvic muscles can increase your risk of a uterine prolapse. Other factors that can increase your risk for the condition include:

  • obesity
  • chronic cough
  • chronic constipation
How is this condition diagnosed?

Your doctor can diagnose uterine prolapse by evaluating your symptoms and performing a pelvic exam. During this exam, your doctor will insert a device called a speculum that allows them to see inside of the vagina and examine the vaginal canal and uterus. You may be lying down, or your doctor may ask you to stand during this exam.

Your doctor may ask you to bear down as if you’re having a bowel movement to determine the degree of prolapse.

How is it treated?

Treatment isn’t always necessary for this condition. If the prolapse is severe, talk with your doctor about which treatment option is appropriate for you.

Nonsurgical treatments include:

  • losing weight to take stress off pelvic structures
  • avoiding heavy lifting
  • doing Kegel exercises, which are pelvic floor exercises that help strengthen the vaginal muscles
  • wearing a pessary, which is a device inserted into the vagina that fits under the cervix and helps push up and stabilize the uterus and cervix

The use of vaginal estrogen has been well-studied and shows improvement in vaginal tissue regeneration and strength. While using vaginal estrogen to help augment other treatment options may be helpful, on its own it doesn’t reverse the presence of a prolapse.

Surgical treatments include uterine suspension or hysterectomy. During uterine suspension, your surgeon places the uterus back into its original position by reattaching pelvic ligaments or using surgical materials. During a hysterectomy, your surgeon removes the uterus from the body through the abdomen or the vagina.

Surgery is often effective, but it’s not recommended for women who plan on having children. Pregnancy and childbirth can put an immense strain on pelvic muscles, which can undo surgical repairs of the uterus.

Cluster headache: causes, symptoms & Treatments

Cluster Headaches

Cluster headaches are a series of relatively short but extremely painful headaches every day for weeks or months at a time. You tend to get them at the same time each year, such as the spring or fall. Because of their seasonal nature, people often mistake cluster headaches for symptoms of allergies or business stress.We don’t know what causes them, but we do know that a nerve in your face is involved, creating intense pain around one of your eyes. It’s so bad that most people can’t sit still and will often pace during an attack. Cluster headaches can be more severe than a migraine, but they usually don’t last as long.These are the least common type of headaches, affecting less than 1 in 1,000 people. Men get them more than women do. You usually start getting them before you’re age 30. Cluster headaches may disappear completely (go into remission) for months or years, but they can come back without any warning.

 

What Happens

You get a cluster headache when a specific nerve pathway in the base of your brain is activated. That signal seems to come from a deeper part of the brain called the hypothalamus, where the “internal biological clock” that controls your sleep and wake cycles lives.

The nerve that’s affected, the trigeminal nerve, is responsible for sensations such as heat or pain in your face. It’s near your eye, and it branches up to your forehead, across your cheek, down your jaw line, and above your ear on the same side, too.An underlying brain condition, such as a tumor or aneurysm, won’t cause these headaches.

Symptoms

Cluster headaches generally reach their full force quickly — within 5 or 10 minutes.

The pain is almost always one-sided, and it stays on the same side during a period, the time when you’re getting daily attacks. (When a new headache period starts, it might switch to the opposite side, but that’s rare.) It’s often described as having a burning or piercing quality. It may be throbbing or constant.

You’ll feel it behind or around one eye. It may spread to your forehead, temple, nose, cheek, or upper gum on that side. Your scalp may be tender. You can often feel your blood pulsing.

A cluster headache lasts a short time — usually 30 to 90 minutes, but maybe as little as 15 minutes or as long as 3 hours — then disappears. You’ll get one to three of these headaches a day.Attacks appear to be linked to the circadian rhythm, your body’s 24-hour clock. They happen so regularly, generally at the same time each day, that they’ve been called “alarm clock headaches.” One will often wake you up an hour or two after you go to bed. Nighttime attacks can be more severe than the daytime ones.Most people will get daily headaches for 2 weeks to 3 months; in between these periods, they’ll be pain-free for at least 2 weeks. About 2 of every 10 people with cluster headaches have less than 14 headache-free days per year.

Cluster headaches don’t make you queasy or throw up. But it’s possible for someone with cluster headaches to also get migraines, which can have those symptoms.

Warning Signs

Although the pain starts suddenly, you may catch a few subtle cues of the oncoming headache on the affected side:

  • Discomfort or a mild burning sensation
  • Swollen or drooping eye
  • Smaller pupil in the eye
  • Eye redness or watering
  • Runny or congested nose
  • Red, warm face

You may begin to sweat a lot, or light may bother you.

Cluster headaches are more common in people who smoke or are heavy drinkers. During a cluster period, you’ll be more sensitive to alcohol and nicotine — just a bit of alcohol can trigger a headache. But drinking won’t trigger one during headache-free periods.

Possible Causes and Triggers

They may include:

  • Cigarette smoke
  • Alcohol
  • Weather changes
  • Strong smells
  • Bright or flashing lights
  • Hot showers

Treatment

The most successful ways to treat the pain are a shot of sumatriptan (Imitrex) and breathing oxygen through a face mask for 20 minutes. Other drugs used for migraines called triptans may work. Prescription medicines based on the ergot fungus and lidocaine nasal spray might also help.

You should take preventive medicine, unless your headache periods last less than 2 weeks. Your doctor can prescribe medication to shorten the length of the cluster as well as lessen the severity of your attacks, including:

  • Divalproex sodium (Depakote)
  • Ergotamine tartrate (Cafergot, Ergomar)
  • Lithium
  • Prednisone, for a short time
  • Verapamil (Calan, Covera, Isoptin, Verelan)

When nothing else has worked, surgery may be an option for people who don’t get a break from cluster headaches. Most of the procedures involve blocking the trigeminal nerve.

Types of Teeth Implants : Details of Procedure

A number of conditions may require oral surgery, including:

Impacted Teeth

Wisdom teeth, otherwise known as third molars, are the last set of teeth to develop. Sometimes these teeth emerge from the gum line and the jaw is large enough to allow room for them, but most of the time, this is not the case. More often, one or more of these third molars fails to emerge in proper alignment or fails to fully emerge through the gum line and becomes entrapped or “impacted” between the jawbone and the gum tissue. Impacted wisdom teeth can result in swelling, pain, and infection of the gum tissue surrounding the wisdom teeth. In addition, impacted wisdom teeth can cause permanent damage to nearby teeth, gums, and bone and can sometimes lead to the formation of cysts or tumors that can destroy sections of the jaw. Therefore, dentists recommend people with impacted wisdom teeth have them surgically removed.

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It’s not just wisdom teeth that sometimes become impacted and need to be removed. Other teeth, such as the cuspids and the bicuspids can become impacted and can cause the same types of problems described with impacted wisdom teeth.

Dental implants are an option for tooth loss due to an accident or infection or as an alternative to bridges and dentures. The implants are tooth root substitutes that are surgically anchored in place in the jawbone and act to stabilize the artificial teeth to which they are attached. Suitable candidates for dental implants need to have an adequate bone level and density, must not be prone to infection, and must be willing to maintain good oral hygiene practices.

Jaw-Related Problems

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  • Unequal jaw growth. In some individuals, the upper and lower jaws fail to grow properly. This can cause difficulty in speaking, eating, swallowing, and breathing. While some of these problems — like improper teeth alignment — can be corrected with braces and other orthodontic appliances, more serious problems require oral surgery to move all or part of the upper jaw, lower jaw, or both, into a new position that is more balanced, functional, and healthy.
  • Improve fit of dentures. For first-time denture wearers, oral surgery can be done to correct any irregularities of the jaws prior to creating the dentures to ensure a better fit. Oral surgery can also help long-term denture wearers. Supporting bone often deteriorates over time, resulting in dentures that no longer fit properly. In severe cases, an oral surgeon can add a bone graft to areas where little bone remains.
  • Temporomandibular joint (TMJ) disorders. Dysfunction of the TMJ, the small joint in front of the ear where the skull and lower jaw meet, is a common source of headache and facial pain. Most patients with TMJ disorders can be successfully treated with a combination of oral medications, physical therapy, and splints. However, joint surgery is an option for advanced cases and when the diagnosis indicates a specific problem in the joint.

Other Conditions Treated By Oral Surgery

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  • Facial injury repair. Oral surgery is often used to repair fractured jaws and broken facial bones.
  • Lesion removal and biopsy.Oral surgeons can take a small sample of abnormal growth or tissue and then send it for laboratory testing for identification. Some lesions can be managed medically or can be removed by the oral surgeon.
  • Cleft lip and cleft palate repair. Cleft lip and cleft palate result when all or portions of the mouth and nasal cavity do not grow together properly during fetal development. The result is a gap in the lip and/or a split or opening in the roof of the mouth. Oral surgeons work as part of a team of health care specialists to correct these problems through a series of treatments and surgical procedures over many years.
  • Facial infections. Pain and swelling in the face, neck, or jaws may indicate an infection. Infections in this area of the body can sometimes develop into life-threatening emergencies if not treated promptly and effectively. An oral surgeon can assist in diagnosing and treating this problem. Surgical treatment, if needed, may include cutting into and draining the infected area, as well as extracting any teeth that might be involved.
  • Snoring/sleep apnea. When conservative nonsurgical methods such as positive pressure air machines and dental splint appliances fail to alleviate this problem, surgery can be tried. Surgical procedures involve removing the soft tissues of the oropharynx (an area in the back portion of the mouth) or the lower jaw. Laser surgery is a newer treatment option.

Lumbar lordosis : causes, symptoms & treatments

The term lordosis means inward curving of a part of the lumber and cervical vertebral column. Excessive lordosis is termed as swayback or saddle back. There are three types of curves which can be present in the human spine.

Scoliotic curves- sideways curvature of the spine; it is always abnormal

Lordotic curves- inward curve of the lumbar spine just above the buttocks

Kyphotic curves- outward curve of the thoracic spine at the level of ribs

A small degree of lordosis and kyphoysis is normally present in the spine. If kyphoysis is too much, it causes round shoulders and is termed as Scheuermann’disease. If lordotic curving is too much, it is termed as swayback or lordosis that makes the buttocks more prominent.

lordosis treatment, Lordosis symptoms, Lordosis exercises

 

Children suffering from too much lordosis will have a space beneath their lower back when lying on their back on a hard surface. When lordotic curve is flexible, it is generally not a concern. When the curve does not move, medical evaluationis needed. Lumber and cervical segments of  the vertebral column are normally lordotic (convexity anteriorly and concavity posteriorly). Anterior pelvic tilt is a major factor of lordosis. Patients with lordosis often show a visible arch in their lower backs. When we look at them from the side, their lower back forms a defined C-shape.

People with lordosis seem to be sticking out their stomachs and buttocks. During examination of the patient with lordosis, ask the patient to lie on his or her back on a hard surface. Can the patient can slide his or her hand under lower back, with a little space to spare? If the patient has lordosis, he or she will have extra space between his or her hand and lower back2,3.

Causes of Lordosis

There are many medical conditions that cause the spine to curve more than normal. These conditions include.

  • Achondroplasia- bones do not grow normally, leading to the short stature.
  • Spondylolisthesis- the vertebrae in the lower back slip forward.
  • Osteoporosis- vertebra become fragile and can easily be broken.
  • Obesity- can cause lordosis.
  • Kyphoysis- can lead to lordosis
  • Discitis- the inflammation of intervertebral disc
  • Benign juvenile lordosis
  • Tight lower back muscles
  • Excessive visceral fat
  • Pregnancy
  • Rickets

Lordosis symptoms

Symptoms of this abnormality depend upon the severity of the disease. Lordosis symptoms may include:

  • C-shape back when seen from a lateral aspect, with the buttocks being more prominent
  • A large gap between the lower back and the floor when lying on one’s back
  • Pain and discomfort in the lower back
  • Problems in moving in certain ways.

Diagnosis

It is difficult to measure and diagnose lordosis. The traditional measurement of lumber lordosis is difficult because of the obliteration of the vertebral end plate landmarks by interbody fusion. L4 –L5 and L5- S1 levels are mostly involved in fusion process, and contribute to normal lumber lordosis. It is useful to identify an accurate means of measuring lordosis at these levels.

Treatment

Treatment of lordosis includes:

  • Pain killer medications to relieve the discomfort and back pain
  • Wearing a back brace
  • Weight loss
  • Vitamin D supplementation
  • Surgery
  • Lordosis exercises

Arthrogryposis: Causes, Symptoms & Treatments

What is Arthrogryposis?

Arthrogryposis is a congenital medical condition in which a child is born with contractures of the joints meaning that some of the joints of the child do not move as fluently as the other more normal joints as if they are stuck in a position. It is also seen in Arthrogryposis that muscles adjacent to the affected joints are quite weak and stiff and in some cases muscles may even be completely missing. There is presence of extra tissues around the joints which make them stuck in one position. These contractures are mostly seen in the arms or the legs but can also be observed in the spine or the jaw. Arthrogryposis is not a single entity but is a feature of many different conditions of which the most common is known as amyoplasia. Children suffering from Arthrogryposis may also suffer from other health conditions impairing the nervous system, heart, kidneys and other vital organs of the body.

What Causes Arthrogryposis?

Arthrogryposis is caused by a condition called as fetal akinesia which means that when the baby is inside the womb of the mother it is not able to move inside as much as it should resulting in underdevelopment of the muscles and joints resulting in Arthrogryposis. When it comes to Fetal Akinesia, this may occur due to the following reasons:

  • Some abnormality in the central nervous system of the child in which the nerve signals do not reach the joints making them move adequately.
  • Another cause may be the womb is not big enough and the baby is cramped up for room and is not able to move adequately inside the womb of the mother.
  • There is an abnormality in the development of the muscles and bones of the tissue.

What are the Symptoms of Arthrogryposis?

Arthrogryposis as stated is a medical condition in which the child is born with joints that are too stiff too move and are stuck in one position. Some of the other accompanying symptoms are:

  • Muscle atrophy or missing muscles
  • Extremely stiff joints
  • Webbing of skin around the affected joints.

Since Arthrogryposis is not a single medical condition hence the child may also have symptoms indicating a problem with the nervous system, heart, kidneys or other vital organs of the body.

How is Arthrogryposis Treated?

The main aim for treating Arthrogryposis is to allow the child to move the affected joints as normally as possible, which means initiating treatments to increase the flexibility of the joint, improving strength of the muscles surrounding the joint, and maintaining a normal alignment of the bones. If the condition has affected the lower extremities then the aim of the treatment is to make the child ambulatory and if the upper extremities are affected then making sure that the child is able to use the hands in as normal way as possible. The following are the treatment strategies adopted for treatment of Arthrogryposis.

Physical/Occupational Therapy for Arthrogryposis: This is the first line of treatment of Arthrogryposis. As soon as the diagnosis of Arthrogryposis is made, the therapy is started to improve the flexibility of the joints affected and to increase strength of the joints. In the initial stage of treatment, the therapist will start with stretching exercises to improve the range of motion and strength of the joint of the child so as to improve their mobility. The therapist will also work on improving the child’s motor skills. In some cases assistive devices may also be needed to help the child become mobile and is able to do things without anybody’s help. Occupational therapists will device strategies to make the child more independent with their movement, writing, eating and the like.

Splinting and Casting: This is the next stage of treatment for Arthrogryposis in which the affected joint is either casted or splinted so that the joints are aligned in a normal way which will help the child move and navigate better and will be able to be independent. The casts and splints allow the joints to remain stretched and thus help prevent development of contractures. The splints that are used may be different for different functions.

It should be noted here that as the child grows the affected joints may not show the same rate of growth as the other muscles and joints of the body and hence ongoing therapy is extremely vital to keep the joints and muscle flexible and strong.

Surgery to Treat Arthrogryposis: This is recommended when the child has maximized improvement with physical therapy and use of splints and casts. The surgery is usually done when the child is a bit older to correct Arthrogryposis. The surgeries performed to correct the condition include osteotomy to align the joints normally for maximal benefits, procedures to release the muscles or tendons which are impairing free movement of the joints, a capsulotomy procedure in case a capsule is restricting the movement, surgeries to treat conditions like scoliosis, clubfoot and the like for treatment of Arthrogryposis.

CAUTI: Causes, Symptoms & Treatments

What Is a Catheter-Associated Urinary Tract Infection (CAUTI)?

A catheter-associated urinary tract infection (CAUTI) is one of the most common infections a person can contract in the hospital. Indwelling catheters are the cause of this infection. An indwelling catheter is a tube inserted into your urethra. It drains urine from your bladder into a collection bag. You may need a catheter if you have had surgery or cannot control your bladder function, and there is a need to closely monitor how much urine your kidneys are producing.

What Are the Symptoms of a CAUTI?

A CAUTI has similar symptoms to a typical urinary tract infection (UTI). These include:

  • cloudy urine
  • blood in the urine
  • strong urine odor
  • urine leakage around your catheter
  • pressure, pain, or discomfort in your lower back or stomach
  • chills
  • fever
  • unexplained fatigue
  • vomiting

CAUTIs can be difficult to diagnose in if you are already hospitalized because similar symptoms may be part of your original illness. In elderly people, changes in mental status or confusion can be signs of a CAUTI.

If you have a catheter and notice any localized discomfort, tell your nurse or doctor right away.

What Causes a CAUTI?

Bacteria or fungi may enter your urinary tract via the catheter. There they can multiply, causing an infection.

There are a number of ways infection can occur during catheterization. For example:

  • the catheter may become contaminated upon insertion
  • the drainage bag may not be emptied often enough
  • bacteria from a bowel movement may get on the catheter
  • urine in the catheter bag may flow backward into the bladder
  • the catheter may not be regularly cleaned

Clean insertion and removal techniques can help lower the risk of a CAUTI. Daily catheter care is required as well. Catheters shouldn’t be left in longer than needed, as longer use is associated with a higher risk of infection.

How Is a CAUTI Diagnosed?

A CAUTI is diagnosed using a urine test. Urinalysis can detect blood cells in your urine. Their presence may signal an infection.

Another useful test is a urine culture. This test identifies any bacteria or fungi in your urine. Knowing what caused the infection can help your doctor treat it.

Sometimes, your bladder doesn’t move urine out of your body quickly enough. This can happen even with a catheter. Retained urine is more likely to grow bacteria. Infection risk increases the longer urine stays in your bladder. Your doctor may recommend an imaging test of your bladder, such as an ultrasound scan, to see if you’re retaining urine.

Potential Complications of a CAUTI

Prompt treatment of a CAUTI is essential. An untreated UTI can lead to a more serious kidney infection. In addition, people with catheters may already have conditions that compromise their immune systems. Fighting off a CAUTI can cause further immune system stress. This makes you more vulnerable to future infections.

How Is a CAUTI Treated?

CAUTIs tend to be more resistant to treatment than other UTIs. This is true in general for hospital-acquired infections. CAUTIs are dangerous because they can lead to severe kidney infections. This makes prompt diagnosis and treatment vital for your long-term health.

Your doctor will likely prescribe antibiotics to kill off any harmful bacteria. In most cases, these will be oral antibiotics. You may be given antibiotics intravenously in the case of a severe infection. If the infection causes bladder spasms, your doctor may prescribe an anti-spasmodic to lessen bladder pain.

Increasing your fluid intake can also help you feel better by flushing bacteria from your urinary system. Certain fluids should be avoided. These include:

  • alcohol
  • citrus fruit juices
  • caffeinated beverages, such as sodas
How Can CAUTIs Be Prevented?

CAUTIs are one of the most common hospital-related infections. Therefore, many healthcare organizations place great emphasis on prevention.

Your doctor will carefully consider whether a catheter is necessary. They’ll also remove a necessary catheter as soon as possible.

In addition, you or the hospital staff should:

  • clean around the catheter each day
  • clean the skin around the catheter each day
  • keep the drainage bag below your bladder
  • empty the drainage bag several times per day
  • keep the catheter tube from kinking
  • wash your hands before and after touching the catheter or drainage bag
  • change the catheter at least once per month

Frequent hand-washing and good hygiene practices on the part of hospital staff can also help prevent CAUTIs.

Heart palpitations: Causes, Symptoms & treatments

They can be bothersome or frightening. They usually aren’t serious or harmful, though, and often go away on their own. Most of the time, they’re caused by stress and anxiety, or because you’ve had too much caffeine, nicotine, or alcohol. They can also happen when you’re pregnant.

Heart palpitations can be a sign of a more serious heart condition. So, if you have heart palpitations, see your doctor. Get immediate medical attention if they come with symptoms:

  • Shortness of breath
  • Dizziness
  • Chest pain
  • Fainting

After your doctor takes your medical history and looks you over, he may order tests to find the cause. If he finds one, the right treatment can reduce or get rid of the palpitations.

If there’s no underlying cause, lifestyle changes can help, including stress management.

Causes

There can be many. Usually, palpitations are either related to your heart or the cause is unknown. Non-heart-related causes include:

  • Strong emotions like anxiety, fear, or stress. They often happen during panic attacks.
  • Vigorous physical activity
  • Caffeine, nicotine, alcohol, or illegal drugs such as cocaine and amphetamines
  • Medical conditions, including thyroid disease, a low blood sugar level, anemia, low blood pressure, fever, and dehydration
  • Hormonal changes during menstruation, pregnancy, or just before menopause. Sometimes, palpitations during pregnancy are signs of anemia.
  • Medications, including diet pills, decongestants, asthma inhalers, and some drugs used to prevent arrhythmias (a serious heart rhythm problem) or treat an underactive thyroid
  • Some herbal and nutritional supplements
  • Abnormal electrolyte levels

Some people have palpitations after heavy meals rich in carbohydrates, sugar, or fat. Sometimes, eating foods with a lot of monosodium glutamate (MSG), nitrates, or sodium can bring them on, too.

If you have heart palpitations after eating certain foods, it could be due to food sensitivity. Keeping a food diary can help you figure out which foods to avoid.

They can also be related to heart disease. When they are, they’re more likely to represent arrhythmia. Heart conditions tied to palpitations include:

  • Prior heart attack
  • Coronary artery disease
  • Heart failure
  • Heart valve problems
  • Heart muscle problems

Diagnosis:

Hepatocellular carcinoma: Causes, Symptoms& Treatments

Hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. Hepatocellular carcinoma occurs most often in people with chronic liver diseases, such as cirrhosis caused by hepatitis B or hepatitis C infection.

Diagnosis

Tests and procedures used to diagnose hepatocellular carcinoma include:

  • Blood tests to measure liver function
  • Imaging tests, such as CT and MRI with contrast, and advanced imaging procedures, such as magnetic resonance elastography
  • Liver biopsy, in some cases, to remove a sample of liver tissue for laboratory testing

Liver cancer is cancer that begins in the cells of your liver. Your liver is a football-sized organ that sits in the upper right portion of your abdomen, beneath your diaphragm and above your stomach.

Several types of cancer can form in the liver. The most common type of liver cancer is hepatocellular carcinoma, which begins in the main type of liver cell (hepatocyte). Other types of liver cancer, such as intrahepatic cholangiocarcinoma and hepatoblastoma, are much less common.

Not all cancers that affect the liver are considered liver cancer. Cancer that begins in another area of the body — such as the colon, lung or breast — and then spreads to the liver is called metastatic cancer rather than liver cancer. And this type of cancer is named after the organ in which it began — such as metastatic colon cancer to describe cancer that begins in the colon and spreads to the liver. Cancer that spreads to the liver is more common than cancer that begins in the liver cells.

Symptoms

Most people don’t have signs and symptoms in the early stages of primary liver cancer. When signs and symptoms do appear, they may include:

  • Losing weight without trying
  • Loss of appetite
  • Upper abdominal pain
  • Nausea and vomiting
  • General weakness and fatigue
  • Abdominal swelling
  • Yellow discoloration of your skin and the whites of your eyes (jaundice)
  • White, chalky stools

Causes

It’s not clear what causes most cases of liver cancer. But in some cases, the cause is known. For instance, chronic infection with certain hepatitis viruses can cause liver cancer.

Liver cancer occurs when liver cells develop changes (mutations) in their DNA — the material that provides instructions for every chemical process in your body. DNA mutations cause changes in these instructions. One result is that cells may begin to grow out of control and eventually form a tumor — a mass of cancerous cells.

Risk factors

Factors that increase the risk of primary liver cancer include:

  • Chronic infection with HBV or HCV. Chronic infection with the hepatitis B virus (HBV) or hepatitis C virus (HCV) increases your risk of liver cancer.
  • Cirrhosis. This progressive and irreversible condition causes scar tissue to form in your liver and increases your chances of developing liver cancer.
  • Certain inherited liver diseases. Liver diseases that can increase the risk of liver cancer include hemochromatosis and Wilson’s disease.
  • Diabetes. People with this blood sugar disorder have a greater risk of liver cancer than those who don’t have diabetes.
  • Nonalcoholic fatty liver disease. An accumulation of fat in the liver increases the risk of liver cancer.
  • Exposure to aflatoxins. Aflatoxins are poisons produced by molds that grow on crops that are stored poorly. Crops such as corn and peanuts can become contaminated with aflatoxins, which can end up in foods made of these products. In the United States, safety regulations limit aflatoxin contamination. Aflatoxin contamination is more common in certain parts of Africa and Asia.
  • Excessive alcohol consumption. Consuming more than a moderate amount of alcohol daily over many years can lead to irreversible liver damage and increase your risk of liver cancer.

Prevention

Reduce your risk of cirrhosis

Cirrhosis is scarring of the liver, and it increases the risk of liver cancer. You can reduce your risk of cirrhosis if you:

  • Drink alcohol in moderation, if at all. If you choose to drink alcohol, limit the amount you drink. For women, this means no more than one drink a day. For men, this means no more than two drinks a day.
  • Maintain a healthy weight. If your current weight is healthy, work to maintain it by choosing a healthy diet and exercising most days of the week. If you need to lose weight, reduce the number of calories you eat each day and increase the amount of exercise you do. Aim to lose weight slowly — 1 or 2 pounds (0.5 to 1 kilograms) each week.
  • Use caution with chemicals. Follow instructions on chemicals you use at home or at work.

Get vaccinated against hepatitis B

You can reduce your risk of hepatitis B by receiving the hepatitis B vaccine, which provides more than 90 percent protection for both adults and children. The vaccine can be given to almost anyone, including infants, older adults and those with compromised immune systems.

Take measures to prevent hepatitis C

No vaccine for hepatitis C exists, but you can reduce your risk of infection.

  • Know the health status of any sexual partner. Don’t engage in unprotected sex unless you’re certain your partner isn’t infected with HBV, HCV or any other sexually transmitted infection. If you don’t know the health status of your partner, use a condom every time you have sexual intercourse.
  • Don’t use intravenous (IV) drugs, but if you do, use a clean needle. Reduce your risk of HCV by not injecting illegal drugs. But if that isn’t an option for you, make sure any needle you use is sterile, and don’t share it. Contaminated drug paraphernalia is a common cause of hepatitis C infection. Take advantage of needle-exchange programs in your community and consider seeking help for your drug use.
  • Seek safe, clean shops when getting a piercing or tattoo. Needles that may not be properly sterilized can spread the hepatitis C virus. Before getting a piercing or tattoo, check out the shops in your area and ask staff members about their safety practices. If employees at a shop refuse to answer your questions or don’t take your questions seriously, take that as a sign that the facility isn’t right for you.

Ask your doctor about liver cancer screening

For the general population, screening for liver cancer hasn’t been proved to reduce the risk of dying of liver cancer, so it isn’t generally recommended. The American Association for the Study of Liver Diseases recommends liver cancer screening for those thought to have a high risk, including people who have:

  • Hepatitis B and one or more of the following apply: are Asian or African, have liver cirrhosis, or have a family history of liver cancer
  • Hepatitis C infection and liver cirrhosis
  • Liver cirrhosis from other causes, such as an autoimmune disease, excessive alcohol use, nonalcoholic fatty liver disease and inherited hemochromatosis
  • Primary biliary cirrhosis

Discuss the pros and cons of screening with your doctor. Together you can decide whether screening is right for you based on your risk. Screening typically involves an ultrasound exam every six months.

Treatment

Which treatment is best for you will depend on the size and location of your hepatocellular carcinoma, how well your liver is functioning, and your overall health.

Hepatocellular carcinoma treatments include:

  • Surgery. Surgery to remove the cancer and a margin of healthy tissue that surrounds it may be an option for people with early-stage liver cancers who have normal liver function.
  • Liver transplant surgery. Surgery to remove the entire liver and replace it with a liver from a donor may be an option in otherwise healthy people whose liver cancer hasn’t spread beyond the liver.
  • Destroying cancer cells with heat or cold. Ablation procedures to kill the cancer cells in the liver using extreme heat or cold may be recommended for people who can’t undergo surgery. These procedures include radiofrequency ablation, cryoablation, and ablation using alcohol or microwaves.
  • Delivering chemotherapy or radiation directly to cancer cells. Using a catheter that’s passed through your blood vessels and into your liver, doctors can deliver chemotherapy drugs (chemoembolization) or tiny glass spheres containing radiation (radioembolization) directly to the cancer cells.
  • Targeted drug therapy. Targeted drugs, such as sorafenib (Nexavar), may help slow the progression of the disease in people with advanced liver cancer.
  • Radiation therapy. Radiation therapy using energy from X-rays or protons may be recommended if surgery isn’t an option. A specialized type of radiation therapy, called stereotactic body radiotherapy (SBRT), involves focusing many beams of radiation simultaneously at one point in your body.
  • Clinical trials. Clinical trials give you a chance to try new liver cancer treatments. Ask your doctor whether you’re eligible to participate in a clinical trial.

Hepatocellular Carcinoma: Causes, symptoms & treatments

Hepatocellular carcinoma usually occurs in patients with cirrhosis and is common in areas where infection with hepatitis B and C viruses is prevalent. Symptoms and signs are usually nonspecific. Diagnosis is based on alpha-fetoprotein (AFP) levels, imaging tests, and sometimes liver biopsy. Screening with periodic AFP measurement and ultrasonography is sometimes recommended for high-risk patients. Prognosis is poor when cancer is advanced, but for small tumors that are confined to the liver, ablative therapies are palliative and surgical resection or liver transplantation is sometimes curative.

Hepatocellular carcinoma is the most common type of primary liver cancer, with an estimated 23,000 new cases and about 14,000 deaths expected in 2012 in the US. However, it is more common outside the US, particularly in East Asia and sub-Saharan Africa where the incidence generally parallels geographic prevalence of chronic hepatitis B virus (HBV) infection.

Overview of Hepatocellular Carcinoma

Etiology

Hepatocellular carcinoma is usually a complication of cirrhosis.

The presence of HBV increases risk of hepatocellular carcinoma by > 100-fold among HBV carriers. Incorporation of HBV-DNA into the host’s genome may initiate malignant transformation, even in the absence of chronic hepatitis or cirrhosis.

Other disorders that cause hepatocellular carcinoma include cirrhosis due to chronic hepatitis C virus (HCV) infection, hemochromatosis, and alcoholic cirrhosis. Patients with cirrhosis due to other conditions are also at increased risk.

Environmental carcinogens may play a role; eg, ingestion of food contaminated with fungal aflatoxins is believed to contribute to the high incidence of hepatocellular carcinoma in subtropical regions.

Symptoms and Signs

Most commonly, previously stable patients with cirrhosis present with abdominal pain, weight loss, right upper quadrant mass, and unexplained deterioration. Fever may occur. In a few patients, the first manifestation of hepatocellular carcinoma is bloody ascites, shock, or peritonitis, caused by hemorrhage of the tumor. Occasionally, a hepatic friction rub or bruit develops.

Occasionally, systemic metabolic complications, including hypoglycemia, erythrocytosis, hypercalcemia, and hyperlipidemia, occur. These complications may manifest clinically.

Diagnosis

  • Alpha-fetoprotein (AFP) measurement

 

  • Imaging (CT, ultrasonography, or MRI)

Clinicians suspect hepatocellular carcinoma if

 

  • They feel an enlarged liver.
  • Unexplained decompensation of chronic liver disease develops.
  • An imaging test detects a mass in the right upper quadrant of the abdomen during an examination done for other reasons, especially if patients have cirrhosis.

However, screening programs enable clinicians to detect many hepatocellular carcinomas before symptoms develop.

Diagnosis is based on AFP measurement and an imaging test. In adults, AFP signifies dedifferentiation of hepatocytes, which most often indicates hepatocellular carcinoma; 40 to 65% of patients with the cancer have high AFP levels (> 400 μg/L). High levels are otherwise rare, except in teratocarcinoma of the testis, a much less common tumor. Lower values are less specific and can occur with hepatocellular regeneration (eg, in hepatitis). Other blood tests, such as AFP-L3 (an AFP isoform) and des-gamma–carboxyprothrombin, are being studied as markers to be used for early detection of hepatocellular carcinoma.

Depending on local preferences and capabilities, the first imaging test may be contrast-enhanced CT, ultrasonography, or MRI. Hepatic arteriography is occasionally helpful in equivocal cases and can be used to outline the vascular anatomy when ablation or surgery is planned.

If imaging shows characteristic findings and AFP is elevated, the diagnosis is clear. Liver biopsy, often guided by ultrasonography or CT, is sometimes indicated for definitive diagnosis.

Staging

If a hepatocellular carcinoma is diagnosed, evaluation usually includes chest CT without contrast, imaging of the portal vein (if not already done) by MRI or CT with contrast to exclude thrombosis, and sometimes bone scanning.

Various systems can be used to stage hepatocellular carcinoma; none is universally used. One system is the TNM system, based on the following (see Table: Staging Hepatocellular Carcinoma*):

  • T: How many primary tumors, how big they are, and whether the cancer has spread to adjacent organs

    N: Whether the cancer has spread to nearby lymph nodes

    M: Whether the cancer has metastasized to other organs of the body

Numbers (0 to 4) are added after T, N, and M to indicate increasing severity.

Staging Hepatocellular Carcinoma*

Screening

On increasing number of hepatocellular carcinomas are being detected through screening programs. Screening patients with cirrhosis is reasonable, although this measure is controversial and has not been shown to reduce mortality. One common screening method is ultrasonography every 6 or 12 mo. Many experts advise screening patients with long-standing hepatitis B even when cirrhosis is absent.

Treatment

  • Transplantation if tumors are small and few

Treatment of hepatocellular carcinoma depends on its stage (1).

For single tumors < 5 cm or  3 tumors that are all  3 cm and that are limited to the liver, liver transplantation results in as good a prognosis as liver transplantation done for noncancerous disorders. Alternatively, surgical resection may be done; however, the cancer usually recurs.

Ablative treatments (eg, hepatic arterial chemoembolization, yttrium-90 microsphere embolization [selective internal radiation therapy, or SIRT], drug-eluting bead transarterial embolization, radiofrequency ablation) provide palliation and slow tumor growth; they are used when patients are awaiting liver transplantation.

If the tumor is large (> 5 cm), is multifocal, has invaded the portal vein, or is metastatic (ie, stage III or higher), prognosis is much less favorable (eg, 5-yr survival rates of about 5% or less). Radiation therapy is usually ineffective. Sorafenib appears to improve outcomes.

Prevention

Use of vaccine against HBV eventually decreases the incidence, especially in endemic areas. Preventing the development of cirrhosis of any cause (eg, via treatment of chronic hepatitis C, early detection of hemochromatosis, or management of alcoholism) can also have a significant effect.

Key Points:

 

  • Hepatocellular carcinoma is usually a complication of cirrhosis and is most common in parts of the world where hepatitis B is prevalent.
  • Consider the diagnosis if physical examination or an imaging test detects an enlarged liver or if chronic liver disease worsens unexpectedly.
  • Diagnose hepatocellular carcinoma based on the AFP level and liver imaging results, and stage it using chest CT without contrast, portal vein imaging, and sometimes bone scanning.
  • Consider liver transplantation if tumors are small and few.
  • Prevention involves use of the hepatitis B vaccine and management of disorders that can cause cirrhosis.
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