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Myiasis

Overview

Myiasis is parasitic infestation of the body of a live animal by fly larvae (maggots) that grow inside the host while feeding on its tissue. It is a condition primarily associated with poor hygiene, open wounds, and occurs more frequently in tropical and subtropical regions. Myiasis often occurs when gravid female flies deposit eggs or larvae directly onto wounds or mucous membranes. Factors increasing risk include untreated wounds, poor oral hygiene, alcoholism, dementia, and immunocompromised states. so, If you suspect you have myiasis, it’s crucial to seek medical attention for proper diagnosis and treatment.

Myiasis can be classified by the affected body area and the relationship of the larvae to the host:
  • Cutaneous myiasisinvolves skin infestation and can be further categorized as furuncular (forming boil-like lesions), wound (infestation of existing wounds), or migratory (larvae moving under the skin). 
  • Cavity myiasisaffects orifices like the mouth, ear, or nose. 
  • Ophthalmic myiasisaffects the eye, causing symptoms like conjunctivitis and lid swelling. 
  • Genital myiasisis rare but can occur, particularly in individuals with conditions like uterovaginal prolapse. 

Causes

  • Myiasis occurs when flies lay their eggs on or near a person’s wound, sore, or other body openings, such as the nose or ears.
  • Some flies may also lay eggs on clothing that is then worn, transferring the larvae to the skin.
  • Risk factors include poor hygiene, unsanitary living conditions, contact with animals, open wounds, and travel to tropical and subtropical areas where myiasis-causing flies are more prevalent.
  • People with compromised immune systems are also at higher risk. 

Symptoms

Symptoms vary depending on the type and location of the infestation but can include:
  • Pain and discomfort.
  • Itching and irritation.
  • A sensation of movement or crawling under the skin.
  • Visible boil-like lesions or lumps.
  • Openings in the center of the lesions where the larvae breathe.
  • Pus-filled bumps.
  • Swelling and tenderness.
  • In some cases, systemic symptoms like fever, chills, and fatigue may occur. 

Diagnosis

Diagnosis is typically based on:
  • A thorough medical history and physical examination.
  • Visual identification of the larvae.
  • In some cases, blood tests or imaging tests may be used.
  • Immunodiagnostic tests may detect antibodies to specific fly species.

Treatment

Treatment options depend on the type of myiasis and may include:
  • Larvae removal: This is the primary treatment. Methods include:
  • Occlusion: Covering the opening of the lesion with a substance like petroleum jelly to suffocate the larva and encourage it to emerge.
  • Mechanical extraction: Removing the larvae with forceps or by applying pressure.
  • Surgical removal: May be necessary for deeply embedded larvae or if other methods fail.
  • Wound care: Thorough cleaning, antiseptic dressings, and debridement are important.
  • Antibiotics: May be prescribed to treat secondary bacterial infections.
  • Anti-parasitic medications: In some cases, medications like oral or topical ivermectin may be used to kill the larvae and facilitate removal.
  • Intestinal myiasis: May resolve on its own, or anti-parasitic medication may be prescribed.

Prevention

  • Maintain good personal hygiene.
  • Properly care for any open wounds or sores.
  • In areas where myiasis is common, take steps to prevent fly bites, such as wearing protective clothing and using insect repellents containing DEET.
  • Dispose of animal carcasses and refuse properly to deny flies breeding grounds. 

Conclusion

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Melanocytic nevus

Overview

Melanocytic nevus is a skin condition characterized by an abnormally dark, noncancerous skin patch (nevus) that is composed of pigment-producing cells called melanocytes. It is present from birth (congenital) or is noticeable soon after birth. Benign nevi are usually round or oval-shaped and are uniform in colour. Melanocytic nevi are a reflection of genetic factors, such as family history, and environmental factors—primarily, sun exposure. As melanocytic nevi age, they often become lighter in color. They may also elevate but should become softer to the touch. Affected individuals may feel anxiety or emotional stress due to the impact the nevus may have on their appearance and their health. Children with giant congenital melanocytic nevus can develop emotional or behavior problems.Treatment options include surgical excision, laser therapy, and other methods. 

Types of Melanocytic Nevi: 

    • Congenital Melanocytic Nevi (CMN): Present at birth or within the first few weeks of life. They can be small, medium, or large/giant, with giant CMNs being of particular concern due to a higher risk of melanoma. 
  • Acquired Melanocytic Nevi: Develop after birth and are often referred to as “moles”. 
  • Dysplastic Nevi (Atypical Moles): These moles have an irregular appearance and may be more likely to develop into melanoma, though most remain benign. 

People with giant congenital melanocytic nevus may have more than one nevus (plural: nevi). The other nevi are often smaller than the giant nevus. Affected individuals may have one or two additional nevi or multiple small nevi that are scattered over the skin; these are known as satellite or disseminated nevi.

Affected individuals may feel anxiety or emotional stress due to the impact the nevus may have on their appearance and their health. Children with giant congenital melanocytic nevus can develop emotional or behavior problems.

Some people with giant congenital melanocytic nevus develop a condition called neurocutaneous melanosis, which is the presence of pigment-producing skin cells (melanocytes) in the tissue that covers the brain and spinal cord. These melanocytes may be spread out or grouped together in clusters. Their growth can cause increased pressure in the brain, leading to headache, vomiting, irritability, seizures, and movement problems. Tumors in the brain may also develop.

Causes

The cause of this condition is not clearly understood, but it is thought to result from a defect in embryologic development during the first 12 weeks of pregnancy. The defect is thought to cause a proliferation of melanocytes, the cells responsible for normal skin color. When melanocytes are produced at an extremely rapid rate, they form in clusters instead of spreading out evenly, resulting in abnormal skin pigmentation in some areas of the body.

Genes can influence a person’s moles. Dysplastic nevus syndrome is a largely hereditary condition that causes a person to have a large quantity of moles (often 100 or more), with some larger than normal or atypical. This often leads to a higher risk of melanoma, a serious type of skin cancer. Dysplastic nevi are more likely than ordinary moles to become cancerous. While dysplastic nevi are common, and many people have a few of these abnormal moles, having more than 50 ordinary moles also increases the risk of developing melanoma.

In the general population, a slight majority of melanomas do not form in existing moles but rather create new growths on the skin. Somewhat surprisingly, this pattern also applies to those with dysplastic nevi. These individuals are at a higher risk of melanoma occurring not only where there is an existing mole but also in areas without moles. Consequently, such persons need regular examinations to check for changes in their moles and to identify any new ones.

Diagnosis

Melanocytic naevi are usually diagnosed clinically by their typical appearance. If there is any doubt about the diagnosis, an expert may be consulted in person or with the help of clinical and dermatoscopic images.

  • A naevus changes size, shape, structure or colour
  • A new naevus develops in adult life (> 40 years)
  • It appears different from the person’s other naevi (a so-called ugly duckling)
  • It has ABCD characteristics (Asymmetry, Border irregularity, Colour variation, Diameter > 6 mm)
  • It is bleeding, crusted or itchy.

Most skin lesions with these characteristics are actually harmless when evaluated by an expert using dermatoscopy. Short-term digital dermatoscopic imaging may be used in equivocal flat lesions to check for change over time.

Naevi that remain suspicious for melanoma are excised for histopathology (diagnostic biopsy). A partial biopsy is not recommended, as it may miss an area of cancerous change.

 Treatment

Most melanocytic naevi are harmless and can be safely left alone. They may be removed in the following circumstances:

  • To exclude cancer
  • If a naevus is a nuisance: perhaps irritated by clothing, comb or razor
  • Cosmetic reasons: the mole is unsightly.

Surgical techniques include:

  • Excision biopsy of a flat or suspicious melanocytic naevus
  • Shave biopsy of a protruding melanocytic naevus
  • Electrosurgical destruction
  • Laser to lessen pigment or remove coarse hair.

At any age, sun protection is important to reduce skin ageing and the risk of skin cancer.

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Dyshidrotic eczema

Overview

Dyshidrotic eczema, also called dyshidrosis or pompholyx, is a type of eczema that causes tiny, itchy blisters and dry skin. It usually affects the skin between your fingers, on your palms and on the soles of your feet. The fluid-filled blisters look like small, cloudy beads. They’re about 1 to 2 millimeters wide — the size of a pinhead. Sometimes, they join together to form a larger blister. When the blisters dry out, your skin may turn scaly and crack. While the exact cause isn’t known, dyshidrotic eczema can be triggered by various factors including allergies, temperature changes, stress etc. You can manage mild symptoms at home between visits. This can help calm your skin.In some cases, oral medications like corticosteroids or immunosuppressants may be prescribed. 

Causes

Healthcare providers don’t know exactly what causes dyshidrotic eczema. They believe that both genes and the environment play a role. This condition can run in biological families. So, if your parent or sibling has it, you might get it, too. Certain things in your environment, like allergens or stress, can also trigger symptoms. Dyshidrotic eczema isn’t contagious. You can’t catch it from someone else. And you can’t spread it through physical contact.

Symptoms

Dyshidrotic eczema causes symptoms that come and go. These may last for several weeks at a time. The most common symptoms affect your skin and may include:

  • Small, firm blisters
  • Pain or soreness
  • Itching
  • Peeling or scaling
  • Changes in color
  • Extra sweating
  • Dryness and cracking (after blisters go away)

In severe cases, blisters may get bigger and spread to the backs of your fingers, hands and feet. They won’t spread to other parts of your body.

Diagnosis and Tests

  • Allergy test
  • Biopsy
  • Blood tests

These can also help rule out other conditions that look similar, like:

  • Contact dermatitis
  • Bullous pemphigoid
  • Hand, foot and mouth disease

Treatment

Treatment for dyshidrotic eczema may include:

  • Avoiding triggers: Your provider can help you figure out and avoid things that make your symptoms worse. This may include using unscented soaps, not wearing nickel jewelry and avoiding foods you’re allergic to.
  • Creating a skincare routine: This condition weakens your skin’s protective barrier. Using extra moisturizer keeps your skin hydrated. It prevents cracking and dryness.
  • Trying at-home remedies: You can manage mild symptoms at home between visits. This can help calm your skin.
  • Using medications: Your provider may prescribe creams or lotions to help your skin heal faster.
  • Treating the underlying cause: If your symptoms link to an underlying condition like athlete’s foot or excess sweating, your provider will treat those.

At-home treatments

You can do a few things at home to make your blisters more comfortable, including:

  • Gently washing the affected areas with mild soap
  • Applying an antibacterial cream or ointment
  • Covering the areas with a bandage or gauze
  • Changing your bandages at least once a day

It can be tempting to pop your blisters, but avoid doing this. The skin over your blisters helps protect the deeper layers from infection.

In addition to caring for blisters, you can try these steps to ease symptoms and help your skin heal:

  • Soak your hands and feet in cool water to help you relax.
  • Apply a cool compress for 10 to 15 minutes to lessen itching, then air dry and moisturize right away.
  • Use unscented moisturizers often throughout the day to help with dryness.

Outlook / Prognosis

What can I expect if I have dyshidrotic eczema?

Dyshidrotic eczema symptoms usually flare up and last about three to four weeks before clearing up. This condition affects everyone differently. You might only have symptoms once. Or you might have frequent flare-ups when you contact triggers like allergens, sweat or stress.

If you have repeated flare-ups, the condition may change your skin over time. Your skin could become dry, cracked or thicker. It can even affect your mental health if flare-ups keep happening. Treatment can help you avoid triggers and manage symptoms so they’re less uncomfortable.

Taking good care of your skin is a great first step to help you feel better. Your healthcare provider can work with you to manage this condition and keep your skin as healthy as possible.

Prevention

How can I prevent dishydrotic eczema flare-ups?

To lower your risk of new symptoms or flare-ups:

  • Use warm (not hot) water when washing your hands and wash your skin right after touching an allergen or known trigger
  • Use gloves when washing dishes or handling harsh chemicals
  • Skip new jewelry if you aren’t sure what it’s made of, and you have a metal allergy
  • Dry your hands and feet well after bathing or swimming

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